Activity

My current research activity (x35) is as follows:

Invited Talks and Posters (22)

  1. American Diabetes Association (ADA) Annual Meeting, McCormick Place Convention Center (West Building), Chicago, IL; Potential for Alterations in Islet Beta-Cell Sphingolipid/Ceramide Axis Contributing to ER Stress Models of Diabetes,  21-25th June 2013
  2. Southeastern Regional Lipid Conference (SERLC), Cashiers, North Carolina, 7-9th November 2012
  3. Auburn Boshell Diabetes (ABD) Day, Auburn, Alabama, USA, 1st March 2012
  4. UAB Postdoctoral Research Day (UAB PRD), UAB, Birmingham, Alabama, USA, 20th February 2012
  5. Southeastern Regional Lipid Conference (SERLC), 46th Meeting, Cashiers, North Carolina; Potential for Alteration in Beta Cell Sphingolipid Pathways Contributing to ER Stress in Models of Diabetes Mellitus 7-9th November 2012
  6. Southeastern Regional Lipid Conference (SERLC), 45th Meeting, Cashiers, North Carolina; Protection of Pancreatic Beta Cells from Fatty Acid Induced Lipotoxicity – An Imaging Analysis.  Cashiers, North Carolina, USA. 7-9th November 2011.
  7. Oxford Community Forum for Health Awareness (OCFHA); Diabetes and Nutrition Awareness and Latest Research Update Event, Oxford Community Saturday School, Oxford, UK  23rd  October 2010
  8. Diabetes UK (DUK) Annual Volunteering Conference, Kings College, London, UK9th October 2010
  9. Eastbourne Senior Forum Health Awareness Day, Eastbourne, UK, 5th October 2010
  10. Diabetes UK (DUK) Speaker Scheme training, South East office, Epsom, 5th May 2010
  11. Diabetes UK (DUK) Annual Networking Day, King’s Cross, London, UK, November, 2010
  12. Diabetes UK (DUK) Annual Networking Day, King’s Cross, London, UK, November, 2009
  13. Diabetes Special Topics, Pharmacy Lectures (Module PYM05), School of Pharmacy and Biomolecular Sciences. Type 2 Diabetes; Drug Therapy and Research, Brighton, UK, May 2009
  14. Diabetes UK (DUK) Annual Professional Conference, Diabetes UK, Scottish Exhibition Conference Centre. Rosiglitazone down-regulates p38 stress activated kinase and prevents pancreatic beta cells from lipotoxicity-induced dysfunction. Glasgow, Scotland, March 2009
  15. Coordination Action on the Aetiology, pathology and prediction of type 1 diabetes in Europe (TONECA) Meeting, Lewes, Sussex, UK, September 2008
  16. Diabetes UK (DUK) Annual Networking Day, Camden, London, UK, October, 2008
  17. mTOR Signalling, Medical Sciences Teaching Centre, University of Oxford, UK,15-16th September 2008
  18. Cell Developmental and Integrative Biology Department 10th Annual Meeting, UAB, Birmingham, Alabama, USA, Saturday 16th February 2013
  19. Diabetes UK (DUK) Annual Professional Conference, Diabetes UK, Liverpool, UK 3-5 March, 2010
  20. European Association for the Study of Diabetes (EASD), 44th Annual Scientific Session. Rosiglitazone Prevents Fatty Acid Induced Increases In Uncoupling Protein 2 Gene Expression And Protects Pancreatic Beta-Cells From Lipotoxicity. Rome, Italy. September 2008.
  21. American Diabetes Association (ADA), San Francisco, Diabetes 57, Supp 1A 467, June 4th-10th 2008
  22. Diabetes UK (DUK) Annual Professional Conference, Diabetes UK, Scottish Exhibition Conference Centre, Glasgow, Scotland, March 05-March 07, 2008

Published Abstracts (5)

  1. Ali, T., Wijesinghe, D.S., Chalfant, C., Lei, X., Turk, J., and Ramanadham, S.,(2013) Potential for Alterations in Islet Beta-Cell Sphingolipid/Ceramide Axis Contributing to ER Stress Models of Diabetes Mellitus, Diabetes,62, (Supplement1). p. 86. doi: 10.2337/db13-1-387. 73rd Scientific Sessions, ADA Conference, Chicago
  2. Ali, T., Landy, C., Marriott, C.E, Harrison, M and Macfarlane, W. M., (2010) Imagining beta-cell lipotoxicity Diabetic Medicine, 27 (38). p. 5.  ISSN 0742-3071
  3. Ali, T., Landy, C., Marriott, C.E, Harrison, M and Macfarlane, W. M., (2009) Rosiglitazone down-regulates p38 stress activated protein kinase and protects pancreatic beta-cells from lipotoxicity-induced dysfunction Diabetic Medicine, 26 (Supplement 1). p.6. ISSN 0742-3071
  4. Ali, T., Landy, C., Marriott, C.E, Crawford, R., Woollhead, A.M, Harrison, M. and Macfarlane, W.M (2008) Rosiglitazone prevents fatty acid induced increases in uncoupling protein 2 gene expression and protects pancreatic beta-cells from lipotoxicity Acta Diabetologica, 51 . p. 200. ISSN 0940-5429
  5. Landy, C*., Ali, T*., Crawford, R., Marriott, C.E, Woollhead, A.M, Harrison, M and Macfarlane, W.M (2008) Rosiglitazone modulates multiple signalling pathways in pancreatic beta cells and protects beta cells from the detrimental effects of free fatty acids Diabetes, 57 (Supplement 1A). p. 467. ISSN 0012-1797 (*First Co-authors). 68th Scientific Sessions, ADA Conference, San Francisco

Published Manuscripts (6)

  1. Ali, T., Kokotos, G., Magrioti, V., Bone, R., Mobley, J. A.,  Hancock, W., Ramanadham, S.,(2013) Characterization of FKGK18 as Inhibitor of Group VIA Ca2+-Independent Phospholipase A2 (iPLA2β): Candidate Drug for Preventing Beta-Cell Apoptosis and Diabetes. PLoS One. Aug 20;8(8):e71748. PMCID: PMC3748103
  2. Lei, X., Bone, R. N., Ali, T., Wohltmann, M., Gai, Y., Goodwin, K. J., Bohrer, A. E., Turk, J., Ramanadham, S., (2013) Genetic modulation of islet β-cell iPLA2β expression provides evidence for its impact on β-cell apoptosis and autophagy. Islets. Jan 1;5 (1). PMCID: PMC3774083
  3. Campbell, S. C., Aldibbiat, Ali., Marriott, C. E., Landy, C., Ali, T., Ferris, W. F., Butler, C. S.,  Shaw, J. A.,  and Macfarlane, W. M. (2008). Selenium stimulates pancreatic beta-cell gene expression and enhances islet function.FEBS Lett. Jun 25;582 (15):2333-7. PMID: 18538137
  4. Ferris, W. F., Marriott, C. E., Ali, T., Landy, C., Campbell, S. C., Macfarlane, W. M., (2010) Tumor Suppressor Pdcd4 Is a Major Transcript That Is Upregulated During In Vivo Pancreatic Islet Neogenesis and Is Expressed in Both Beta-Cell and Ductal Cell Lines. Pancreas. Jan; 40(1):61-6. PMID: 20871477

Under Revision (2)

  1. Ali, T., Wijesinghe, D. S., Chalfant, C. E., Lei, X. and Ramanadham, S., Impact of Calcium-Independent Phospholipase (iPLA2β) and ER Stress on Beta-cell Sphingolipids (FEBS Letters)
  2. Bone, R. N., Gai, Y.,  Kokotos, G., Magrioti, V, Ali, T., Steele, C., Tse, H., Ramanadham, S., Inhibition of iPLA2β Ameliorates Islet Infiltration and Incidence of Diabetes in NOD (Diabetes)
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